- a region in the eastern United States, in the area of the southern Appalachian Mountains, usually including northeastern Alabama, northwestern Georgia, northwestern South Carolina, western North Carolina, eastern Tennessee, western Virginia, eastern Kentucky, West Virginia, western Pennsylvania, and eastern Ohio.
- a Paleozoic landmass, the erosion of which provided the sediments to form the rocks of the Appalachian Mountains.
- a highland region of the eastern US, containing the Appalachian Mountains, extending from Pennsylvania to Alabama
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