- an arm of the Caribbean between northeastern Panama and northwestern Colombia.
- former name of the Isthmus of Panama.
- a town in southwestern Connecticut.
- a city in northeastern Illinois.
- the E part of the Isthmus of Panama, between the Gulf of Darien on the Caribbean coast and the Gulf of San Miguel on the Pacific coast; chiefly within the republic of Panama but extending also into Colombia: site of a disastrous attempt to establish a Scottish colony in 1698
- Isthmus of Darien the former name of the Isthmus of Panama
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