- anew; afresh; again; from the beginning: We reviewed the court’s decision de novo during the rehearing.
- independently of external forces; from within; spontaneously:Mutations associated with autism often occur de novo rather than through inheritance.
- occurring or arising spontaneously or independently of external forces; spontaneous:de novo mutations;de novo synthesis of steroids from cholesterol.
- made from scratch rather than developed from or based on something preexisting, and hence new, novel, or of a new type:de novo protein design;de novo banks.
- De No·vo, noting or related to a type of FDA classification allowing novel medical devices with no precedent on the market to be sold:a De Novo request; De Novo classification.
- from the beginning; anew
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