- loss of hope; hopelessness.
- someone or something that causes hopelessness: He is the despair of his mother.
- to lose, give up, or be without hope (often followed by of): to despair of humanity.
- to give up hope of.
- to lose or give up hope
- to give up hope of; lose hope in
- total loss of hope
- a person or thing that causes hopelessness or for which there is no hope
