- the wife of the U.S. president, or the wife of a current governor or mayor.
- the wife of the head of any country: the First Lady of Brazil.
- the foremost woman in any art, profession, or the like: Helen Hayes, the first lady of American theater.
- (in the US) the wife or official hostess of a chief executive, esp of a state governor or a president
- a woman considered to be at the top of her profession or art
