- a vast plateau in the Republic of South Africa, in Cape of Good Hope province. 100,000 square miles (260,000 square kilometers); 3000–4000 feet (900–1200 meters) above sea level.
- an arid South African tableland with red clay soil.
- any of several high arid plateaus in South Africa, esp the Central Karoo and the Little Karoo. The highveld, north of the Central Karoo, is sometimes called the Northern Karoo
- a period or rock system in Southern Africa equivalent to the period or system extending from the Upper Carboniferous to the Lower Jurassic: divided into Lower and Upper Karoo
- of, denoting, or formed in the Karoo period
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