- to set free; release; They let the captured mouse loose in a field.
- to allow to act freely (often followed by on): I have my medical students practice putting IVs in me before I let them loose on patients.
- to act in a relaxed or uninhibited way: It took some time to talk my dad into letting loose and playing a few games with the grandkids.I can be serious when I need to be, but sometimes I just need to let loose and have fun.
- to utter or issue forcefully and suddenly (sometimes followed by with): I let loose a shriek and made a dive for the door.He let loose with a flurry of angry posts on the website.
- to give way; yield: The guardrail let loose and we very nearly plunged over the edge.
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