- a person who seems to lack direction or a sense of belonging in life: He was described as a "lost soul" who was estranged from his family and fell into crime.The film focuses on four lost souls: a disgraced TV anchor, a rebellious teen, an isolated single mom, and a self-absorbed music nerd.
- a person on the way to hell or perdition: Their preaching focused on bringing lost souls to repentance through God's love.
- the damned soul or restless spirit of a dead person: Ghosts are spirits who cannot reincarnate again, and are miserable lost souls.