- a spot or blotch, especially on one's skin; macule.
- Ophthalmology.
- an opaque spot on the cornea.
- an irregularly oval, yellow-pigmented area on the central retina, containing color-sensitive rods and the central point of sharpest vision.
- a small spot or area of distinct colour, esp the macula lutea
- any small discoloured spot or blemish on the skin, such as a freckle
