- to inject a narcotic, especially heroin, directly into a vein.
- to use or enjoy something without restriction: to mainline on TV movies.
- to inject (a narcotic, especially heroin) directly into a vein.
- to use, enjoy, or imbibe (something) without restriction: mainlining coffee all day long.
- having a principal, established, or widely accepted position; major; mainstream: the membership of mainline churches.
- a principal line or route of a railroad, as contrasted with a branch or secondary one.
- a principal highway.
- Slang.
- a prominent and readily accessible vein of the body that may be used for a narcotic's injection.
- the act of mainlining.
- a fashionable residential district west of Philadelphia.
- any fashionable district where socially prominent people live.
- railways
- the trunk route between two points, usually fed by branch lines
- (as modifier)
- a main road
- to inject a drug into a vein
- having an important position, esp having responsibility for the main areas of activity