- an intoxicating beverage distilled from the fermented juice of certain species of agave.
- any agave yielding this spirit.
- either of two species of spineless, dome-shaped cactus, Lophophora williamsii or L. diffusa, of Texas and northern Mexico, yielding the hallucinogen peyote.
- a spineless globe-shaped cactus, Lophophora williamsii, of Mexico and the southwestern US. Its button-like tubercles (mescal buttons) contain mescaline and are chewed by certain Indian tribes for their hallucinogenic effects
- a colourless alcoholic spirit distilled from the fermented juice of certain agave plants
