- any plant of the genus Urtica, covered with stinging hairs.
- any of various allied or similar plants.
- to irritate, annoy, or provoke.
- to sting as a nettle does.
- to undertake or tackle an unpleasant task.
- any weedy plant of the temperate urticaceous genus Urtica, such as U. dioica (stinging nettle), having serrated leaves with stinging hairs and greenish flowers
- any of various other urticaceous plants with stinging hairs or spines
- any of various plants that resemble urticaceous nettles, such as the dead-nettle, hemp nettle, and horse nettle
- to attempt or approach something with boldness and courage
- to bother; irritate
- to sting as a nettle does
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