- a disease characterized by multiple skin pustules, as smallpox.
- syphilis.
- a disease of sweet potatoes, characterized by numerous pitlike lesions on the roots, caused by a fungus, Streptomyces ipomoea.
- (used as an interjection to express distaste, rejection, aversion, etc.): A pox on you and your bright ideas!
- any disease characterized by the formation of pustules on the skin that often leave pockmarks when healed
- the pox an informal name for syphilis
- an expression of intense disgust or aversion for someone
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