- a small North American mammal, Mephitis mephitis, of the weasel family, having a black coat with a white, V-shaped stripe on the back, and ejecting a fetid odor when alarmed or attacked.
- any of several related or similar animals.
- a thoroughly contemptible person.
- an unidentified ship or target.
- to defeat thoroughly in a game, especially while keeping an opponent from scoring: The team skunked the favorites in the crucial game.
- any of various American musteline mammals of the subfamily Mephitinae, esp Mephitis mephitis (striped skunk), typically having a black and white coat and bushy tail: they eject an unpleasant-smelling fluid from the anal gland when attacked
- a despicable person
- a strain of cannabis smoked for its exceptionally powerful psychoactive properties
- to defeat overwhelmingly in a game
