- any of several U.S. space vehicles consisting of a reusable manned orbiter that touches down on a landing strip after an orbital mission, two reusable solid rocket boosters that drop off after initial ascent, and an expendable external tank containing liquid propellants.
- any of a series of reusable US space vehicles (Columbia (exploded 2003), Challenger (exploded 1986), Discovery, Atlantis, Endeavour) that can be launched into earth orbit transporting astronauts and equipment for a period of observation, research, etc, before re-entry and an unpowered landing on a runway; the first operational flight occurred in 1981 and it was taken out of service in 2011
