- to render (an animal or person) unable to reproduce sexually, as by removing the testicles or ovaries: A gelding is a male horse that has been unsexed and cannot breed.
- to deprive (oneself or another person) of the qualities or character considered typical or desirable for one's gender: Those against female suffrage claimed that the right to vote would unsex women, leaving them unable to care for their homes and children.
- to deprive (a person) of the attributes of his or her sex, esp to make a woman more callous