- either of the two top-tier baseball leagues (the American League and the National League) that are organized under and regulated by MLB.
- a league of corresponding stature in certain other sports, such as ice hockey, soccer, football, or basketball.
- of or relating to the major leagues, especially in baseball.
- belonging to or among the best or most important of its kind: a major-league orchestra.
- a league of highest classification in baseball, football, hockey, etc
