- a change or variation occurring in the course of something.
- interchange or alternation, as of states or things.
- successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.
- regular change or succession of one state or thing to another.
- change; mutation; mutability.
- variation or mutability in nature or life, esp successive alternation from one condition or thing to another
- a variation in circumstance, fortune, character, etc
